Tesofensine

$180.00

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Buy Tesofensine

Tesofensine is a potent oral investigational drug primarily researched for the treatment of obesity. It belongs to a rare class of medications known as triple monoamine reuptake inhibitors (SNDRIs).

Core Mechanism and Effects

Tesofensine modulates brain chemistry by preventing the reabsorption of three critical neurotransmitters:

Dopamine: Influences reward pathways to reduce food cravings and emotional eating Tesofensine.
Serotonin: Enhances signals of satiety (fullness), helping individuals feel satisfied with less food.
Norepinephrine: Suppresses appetite and potentially increases resting energy expenditure (metabolic rate).

Clinical Efficacy (Weight Loss)

Clinical trials, particularly Phase 2 studies, have demonstrated significant efficacy, often cited as nearly double that of older-generation anti-obesity drugs:

Typical Results: At a dose of 0.5 mg daily, participants have shown a mean weight loss of approximately 10.6% to 11.4% over 24 weeks
- Comparison: Its results are considered comparable to some high-efficacy GLP-1 agonists but delivered in a once-daily oral tablet rather than an injection.
Status and Availability
- FDA Status: As of 2026, Tesofensine has not yet received FDA approval for general commercial use in the United States and remains an Investigational New Drug.
- Mexico: .Hypothalamic Obesity: A combination treatment of tesofensine and metoprolol (called Tesomet) has received Orphan Drug Designation from the FDA for treating hypothalamic obesity and Prader-Willi Syndrome.
Side Effects and Safety
- Gastrointestinal: Dry mouth (most common), nausea, constipation, and diarrhea.
- Neurological: Insomnia, headaches, and increased anxiety.
  - 1. Uses of AOD-9604
    - Osteoarthritis and Bone Health: Studied for its regenerative properties in cartilage. Researchers use it to investigate the repair of damaged joints and to improve bone mineral density [4, 5].
    - Localized Fat Reduction: Frequently used in studies involving subcutaneous administration to target stubborn visceral adipose tissue [4].
    - 3. Uses of Tesofensine
      
      Triple Neurotransmitter Modulation: Used as a potent oral treatment to manage appetite, satiety, and cravings simultaneously by increasing levels of dopamine, serotonin, and norepinephrine in the brain [7, 8].
      
      Hypothalamic Obesity: In 2026, it is a primary candidate (often in the combination form Tesomet) for treating rare forms of obesity caused by damage to the hypothalamus (e.g., following brain tumor surgery) [9].
      
      Energy Expenditure: Used in clinical settings to investigate increases in the body’s resting metabolic rate, allowing subjects to burn more calories even while sedentary [8].