BUY 5-Amino-1MQ
I5-Amino-1-methylquinolinium (commonly known as 5-Amino-1MQ) is a specialized metabolic molecule utilized in research and longevity medicine to enhance cellular energy and promote fat loss. Unlike many peptides, it is a small molecule that is orally bioavailable (taken in capsule form).
Core Mechanism: NNMT Inhibition
The primary function of 5-Amino-1MQ is to inhibit the enzyme Nicotinamide N-methyltransferase (NNMT).
- The Problem: As humans age or gain weight, NNMT levels increase. This enzyme “wastes” methyl groups and depletes NAD+ levels in fat and muscle cells, which slows down metabolism and reduces cellular energy.
- The Solution: By blocking NNMT, 5-Amino-1MQ prevents the depletion of NAD+. This preserves the fuel necessary for mitochondrial function and activates the SIRT1 longevity gene, effectively “resetting” the cell’s metabolic efficiency. Research on NNMT inhibitors suggests this pathway is critical for treating metabolic disorders.
Primary Benefits and Research Uses
- Targeted Fat Loss: It promotes the reduction of white adipose tissue (fat) by increasing the metabolic rate of fat cells, making it a focus for studies on obesity and metabolic syndrome.
- Enhanced Energy and Endurance: By increasing intracellular NAD+ levels, it improves mitochondrial energy production (ATP), leading to better physical stamina and reduced fatigue.
- Anti-Inflammatory Properties: Research in 2026 explores its role in reducing systemic inflammation, which is a major driver of chronic disease.
Administration and Typical Protocol
- Format: Usually provided in 50mg or 100mg capsules.
Safety and Regulatory Status
- Sports Status: It is a prohibited substance in competitive sports under the World Anti-Doping Agency (WADA) guidelines.
Disclaimer: This information is for educational purposes. -
1. Targeted Fat Loss and Obesity ResearchThe most significant use of 5-Amino-1MQ is for reducing adipose (fat) tissue, particularly stubborn visceral fat.
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- Mechanism: By inhibiting NNMT, the molecule increases the metabolic rate of fat cells, making them burn energy rather than store it [Nature Communications].
- Outcome: Researchers use it to investigate weight loss that originates from increased energy expenditure rather than appetite suppression.
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2. Muscle Preservation and RecoveryUnlike many fat-loss compounds that can lead to muscle wasting, 5-Amino-1MQ is used to support muscle integrity.-
- Muscle Stem Cells: It is studied for its ability to increase the proliferation of satellite cells (muscle stem cells), which are essential for repairing damaged muscle fibers.
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