brp peptide

• Origin: BRP is a natural peptide hormone produced by the enzymatic cleavage of the larger BRINP2 protein within the brain, particularly in the hypothalamus region that controls appetite and metabolism.
• Unique Action: Unlike GLP-1 agonists (like Ozempic), BRP works independently of the GLP-1 receptor and leptin pathways. Instead, it appears to activate specific G-protein coupled receptors in the hypothalamus, which triggers the CREB-FOS signaling pathway. This distinct mechanism is why it avoids gastrointestinal side effects. 

• Appetite Suppression: In animal studies (mice and pigs), BRP injections reduced food intake by up to 50%.
  • Fat-Specific Weight Loss: Obese mice treated with BRP lost significant amounts of subcutaneous white adipose tissue, brown adipose tissue, and body weight without reducing lean muscle mass.
  • Improved Metabolism: It improved glucose and insulin tolerance in obese animal models.
  • Fewer Side Effects: Critically, the appetite suppression was not associated with anxiety-like behavior, nausea, or changes in bowel movements, which are common with other weight-loss drugs. 
  Status and Future Outlook (2026)
  • FDA Status: BRP is currently an investigational new drug and is not FDA-approved for human consumption. It is strictly available for “research use only”.
  • Clinical Trials: The researchers have secured patents and co-founded a company, Merrifield Therapeutics, with plans to launch human clinical trials in the near future to determine if it is safe and effective in humans.
  • Potential: Due to its unique mechanism and lack of side effects in animal models, BRP is considered a promising potential alternative to the current generation of weight-loss medications